季乃云

 

                 

 

季乃云,男,1980年生,研究员,博士生导师,美国俄克拉荷马大学博士后,“中国科学院院长特别奖”获得者,硕士生导师。研究领域为天然药物化学,研究方向为海岸带盐生植物、藻类植物及其共附生微生物源新型农用抗生素的开发,重点运用化学表观遗传修饰技术对海岸带植物共附生真菌中功能性沉默次生途径产物进行研究。目前已从海岸带生物中分离鉴定的化合物超过300个,结构类型涵盖倍半萜、二萜、二倍半萜、三萜、二萜生物碱、生物碱、聚醚、甾体等,其中新化合物50余个,新骨架1个,特别是发现了大量的卤代结构,并且发现部分结构具有显著的抗虫和抗菌活性。在国内外重要学术期刊上发表研究论文30余篇,申请发明专利近10项。承担科研项目包括中国科学院知识创新工程重要方向性项目、中国科学院院长特别奖获得者科研启动专项资金资助项目、山东省自然科学基金、烟台市科学技术发展计划项目等,并参与中国科学院海岸带微生物网络实验室。

 

          

 

    

 

代表性研究成果:

2011年

1 Ming-Feng Qiao, Nai-Yun Ji*, Feng-Ping Miao, Xiu-Li Yin. Steroids and an oxylipin from an algicolous isolate of Aspergillus flavus. Magnetic Resonance in Chemistry, 2011, in press.

2010年

1 Ming-Feng Qiao, Nai-Yun Ji*, Xiang-Hong Liu, Ke Li, Qing-Mei Zhu, Qin-Zhao Xue. Indoloditerpenes from an algicolous isolate of Aspergillus oryzae. Bioorganic & Medicinal Chemistry Letters, 2010, 20(19), 5677–5680.

2 Ming-Feng Qiao, Nai-Yun Ji*, Xiang-Hong Liu, Fang Li, Qin-Zhao Xue. Asporyergosterol, A new steroid from an algicolous isolate of Aspergillus oryzae. Natural Product Communications, 2010, 5(10), 1575–1578.

3  Nai-Yun Ji, Xiao-Ming Li, Bin-Gui Wang. Sesquiterpenes and other metabolites from the marine red alga Laurencia composita (Rhodomelaceae). Helvetica Chimica Acta, 2010, 93(11), 2281–2286.

2009年

1  Nai-Yun Ji*, Wei Wen, Xiao-Ming Li, Qin-Zhao Xue, Hua-Ling Xiao, Bin-Gui Wang. Brominated selinane sesquiterpenes from the marine brown alga Dictyopteris divaricata. Marine Drugs, 2009, 7(3), 355–360.

2 Yuan-Yuan Qiao, Nai-Yun Ji*, Wei Wen, Xiu-Li Yin, Qin-Zhao Xue. A new epoxy-cadinane sesquiterpene from the marine brown alga Dictyopteris divaricata. Marine Drugs, 2009, 7(4), 600–604.

3 Wei Wen, Fang Li, Nai-Yun Ji*,Xiao-Ming Li, Chuan-Ming Cui, Xiao-Dong Li, Li-Na Zhang, Qin-Zhao Xue, Bin-Gui Wang. A new cadinane sesquiterpene from the marine brown alga Dictyopteris divaricata. Molecules, 2009, 14(6), 2273–2277.

4 Nai-Yun Ji, Xiao-Ming Li, Ke Li, Bin-Gui Wang. Halogenated sesquiterpenes from the marine red alga Laurencia saitoi (Rhodomelaceae). Helvetica Chimica Acta,2009, 92(9), 1873–1879.

2008年

1 Nai-Yun Ji*, Xiao-Ming Li, Bin-Gui Wang. Halogenated terpenes and a C15-acetogenin from the marine red alga Laurencia saitoi. Molecules, 2008, 13(11), 2894–2899.

2 Nai-Yun Ji, Xiao-Ming Li, Hua Xie, Jian Ding, Ke Li, Lan-Ping Ding, Bin-Gui Wang. Highly oxygenated triterpenoids from the marine red alga Laurencia mariannensis (Rhodomelaceae). Helvetica Chimica Acta, 2008, 91(10), 1940–1946.

3 Nai-Yun Ji, Xiao-Ming Li, Ke Li, James B Gloer, Bin-Gui Wang. Halogenated sesquiterpenes and nonhalogenated linear C15-acetogenins from the marine red alga Laurencia composita and their chemotaxonomic significance. Biochemical Systematics and Ecology,2008, 36(12), 938–941.

4 Nai-Yun Ji, Xiao-Ming Li, Ke Li, Lan-Ping Ding, Bin-Gui Wang. Laurane-derived sesquiterpenes from the marine red alga Laurencia tristicha (Rhodomelaceae). Natural Product Research, 2008, 22(8), 715–718.

2007年

1 Nai-Yun Ji, Xiao-Ming Li, Ke Li, Bin-Gui Wang. Laurendecumallenes A–B and laurendecumenynes A–B, halogenated nonterpenoid C15-acetogenins from the marine red alga Laurencia decumbens. Journal of Natural Products, 2007, 70(9), 1499–1502.

2 Nai-Yun Ji, Xiao-Ming Li, Ke Li, Lan-Ping Ding, James B Gloer, Bin-Gui Wang. Diterpenes, sesquiterpenes, and a C15-acetogenin from the marine red alga Laurencia mariannensis. Journal of Natural Products, 2007, 70(12), 1901–1905.

3 Nai-Yun Ji, Xiao-Ming Li, Lan-Ping Ding, Bin-Gui Wang. Aristolane sesquiterpenes and highly brominated indoles from the marine red alga Laurencia similis (Rhodomelaceae). Helvetica Chimica Acta,2007, 90(2), 385–391.

 

4 Nai-Yun Ji, Xiao-Ming Li, Chuan-Ming Cui, Bin-Gui Wang. Terpenes and polybromoindoles from the marine red alga Laurencia decumbens (Rhodomelaceae). Helvetica Chimica Acta,2007, 90(9), 1731–1736.

5 Nai-Yun Ji, Xiao-Ming Li, Yi Zhang, Bin-Gui Wang. Two new halogenated chamigrane-type sesquiterpenes and other secondary metabolites from the marine red alga Laurencia okamurai and their chemotaxonomic significance. Biochemical Systematics and Ecology,2007, 35(9), 627–630.

 

招生方向:海洋资源化学、海岸带生物工程、天然药物化学、天然药物开发

招生方向简介:以天然产物化学和生物合成研究为基础,重点开展海岸带耐盐植物及其共生微生物与海岸带特殊环境来源的非共生微生物次级代谢产物在农业、食品和医药方面的应用研究,以及海岸带微生物的诱导代谢与生物转化研究;以天然药物开发为目标,重点开展海岸带耐盐植物及其共生微生物与海岸带特殊环境来源的非共生微生物次级代谢产物在农业、食品和医药方面的应用研究,以及海岸带微生物的诱导代谢与生物转化研究。

 联系方式:Tel:0535-2109176;E-mail: nyji@yic.ac.cn。



版权所有©中国科学院烟台海岸带研究所
地址:山东省烟台市莱山区春晖路17号  邮编:264003
备案序号:鲁ICP备10010756号  烟公网安备37060202000025号